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Randomized Trial of Exemestane After Two to Three Years of Tamoxifen Therapy in Postmenopausal Women With Primary Breast Cancer.

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We also examined the association between the CYP3A5 genotypes and serum levels of tamoxifen and its metabolites.

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28 Patients in complete remission for many years may be able to discontinue AZA or 6MP, but continuing therapy may be beneficial in most patients.

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Three cases of liver cancer were reported in the tamoxifen group vs.

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The target gene mRNA levels were evaluated by the StepOne Real-time PCR System (Applied Biosystems) using cDNAs converted from total RNA with SuperScript III Reverse Transcriptase (Invitrogen).

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Instead, we tend to compare experimental treatment versus standardofcare or compare adding experimental treatments to the standard of care to the standard of care alone.

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Our large, multicenter study challenges the concept of five years of monotherapy with endocrine agents after the surgical treatment of primary breast cancer.

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Tamoxifen induced significantly more side-effects than acetyl-L-carnitine.

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This allowed us to completely ascertain the total duration of tamoxifen treatment and the extent to which co-prescription of potentially interacting medications occurred during the course of treatment.

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The numbers of women evaluated at each of the five follow-up visits were 70, 68, 67, 64, and 62 in the placebo group and 66, 66, 65, 64, and 64 in the tamoxifen group, respectively (1 woman in the placebo group did not undergo measurement of bone mineral density at the final visit).

Tamoxifen is more promiscuous than raloxifene in target sites because of the relationship between ER's amino acid in Asp-351 and the antiestrogenic side chain of the SERM.

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In the NSABP P-1 trial, tamoxifen citrate treatment lowered the risk of developing breast cancer during the follow-up period of the trial, but did not eliminate breast cancer risk (see CLINICAL PHARMACOLOGY section of Prescribing Information).

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